Single-Analyte Analysis
Within CellTIVITY, we develop a lab-on-a-chip-based platform for any biomarker class, including cells, exosomes, and proteins. Our focus is on integrating workflows that include microfluidic pumps, incubation, magnetic manipulation, sensing, and data analysis. For various in vitro diagnostic applications, such as stochastic sensing, we apply magnetic and image sensing.
Label-free Imaging Cytometry
We combine quantitative phase imaging, microfluidics and image analysis algorithms for biomedical applications. This method requires minimal sample preparation and is used in the medical fields of hematology, oncology and parasitology.
Group Leader: Ellen Emken (ellen.emken@tum.de)
Live Tissue Analysis
The processing and sensor-based, dynamic analysis of live tissues is essential to meet clinical demands both for in-vitro settings (e.g. for diagnostics on explanted human samples) and active implanted devices in vivo. Ideally, this means immediate translation of biomedical engineering developments to improve therapies.
Group Leader: Martin Brischwein (brischwein@tum.de)
CellFACE @ TUM-CREATE Singapore
The Chair leads a team of interdisciplinary (A*Star, MRI, NTU, NUS, NUHS, Sunningdale Ltd, TUM) for the NRF project “CellFACE - Imaging-based Flow Cytometry for Hidden Haematology Biomarker”. Within a clinical study at NUHS, the team will demonstrate the diagnostic opportunities of blood cell interactions currently hidden for the routine diagnostics.
Biomedical Acoustofluidics
The feedback-controlled acoustofluidic platform technology CellLEGO enables contact-free three-dimensional cultivation, manipulation, and quantitative analysis of cells and spheroids under near-physiological conditions with controlled perfusion and temperature. This technology can be integrated with any microscope method for continuous monitoring and tomography in a microfluidic environment.
Paper-based Diagnostic coupled with AI
BugSense
BugSense develops and integrates paper-based biosensing, bacterial culture, and digital readout technologies to enable rapid point-of-care diagnostics for urinary tract infections. Our platform combines biochemical assays with controlled incubation and image-based analysis to detect bacterial presence, identify pathogens, quantify bacterial load, and assess antimicrobial resistance.
Group Leader: Sarah Wali